Theoretical study on gold nanocluster (nAu=5, 6,7,9,11,12)conjugated to folat with 4-amino thiophenol as a linker for tumortargeted drug delivery
عنوان مقاله: Theoretical study on gold nanocluster (nAu=5, 6,7,9,11,12)conjugated to folat with 4-amino thiophenol as a linker for tumortargeted drug delivery
شناسه ملی مقاله: NCTCC04_202
منتشر شده در چهارمین همایش ملی فن آوری های نوین شیمی و مهندسی شیمی در سال 1394
شناسه ملی مقاله: NCTCC04_202
منتشر شده در چهارمین همایش ملی فن آوری های نوین شیمی و مهندسی شیمی در سال 1394
مشخصات نویسندگان مقاله:
Z Bayat - DepartmentofChemistry,QuchanBranch,IslamicAzadUniversity-Quchan,Iran
M Hajipoor - DepartmentofChemistry,QuchanBranch,IslamicAzadUniversity-Quchan,Iran
خلاصه مقاله:
Z Bayat - DepartmentofChemistry,QuchanBranch,IslamicAzadUniversity-Quchan,Iran
M Hajipoor - DepartmentofChemistry,QuchanBranch,IslamicAzadUniversity-Quchan,Iran
Nano science as a new scientific in various branches of science have been made many changes. Gold nanoclusters (AuNCs) provide non-toxic carriers for drug and gene delivery applications. An additional attractive feature of AuNCs is their interaction with thiols, providing an effective and selective means of controlled intracellular release. We also know that folate receptor (FR) is a confirmed tumor-associated antigen that binds folate and folate–drug conjugates with very high affinity and shuttles these bound molecules inside cells via an endocytic mechanism. Now we have a folate connecting by the linker 4-amino thiophenol to three gold nanoclusters (AuNC).Folate is the generic term for folic acid and structurally related compounds that have the biochemical activity of folic acid. Due to folate’s promising characteristics of non-immunogenic, specificity for cancer, and its possible conjugation with gold nanoclusters (AuNC) as reported here, folate-AuNC nanoconjugate is a front-runner as a targeting moiety for many cancer nanotechnology treatments.
کلمات کلیدی: 4amino thiophenol, Anti-cancerdrug, folate, gold nanocluster, DFT and HFcalculations
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/462342/