Pro-inflammatory cytokines independently of TGF-β are required for human Th17 cell differentiation

T helper-17 (Th17) cells are a CD4+ Th subset that plays a critical role in pathophysiology of several inflammatory disorders, autoimmune diseases and organ transplant rejection and characterized by production of IL-17, IL-21, IL-22 and expression of transcription factor RORC. The differentiation of human CD4+ T cells into Th17 cells requires combination of pro-inflammatory cytokines. Regarding discrepancies that exist among different studies which have tried to clarify critical factors especially TGF-β in human Th17 cell differentiation, the aim of this study was to identify the best condition for Th17 cell development.

Keywords:

Th17 cell differentiation , IL-17 , TGF-β , Treg , Th17 , 1 cell| Foxp3 , Pro-inflammatory cytokines