The bioinformatics study of listeriolysin O protein
Publish Year: 1394
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
NCNCMB02_310
تاریخ نمایه سازی: 12 تیر 1395
Abstract:
Listeriolysin O protein (LLO) is a pore-forming toxin of the cholesterol-dependent cytolysin family and a primary virulence factor of the gram-positive, facultative intracellular pathogen Listeria monocytogenes, an opportunistic bacterial pathogen responsible for the disease listeriosis. This disease starts with the ingestion of contaminated foods and mainly affects immunocompromised individuals, newborns, and pregnant women. In the laboratory, L. monocytogenes is used as a model organism to study processes such as cell invasion, intracellular survival, and cell-to-cell spreading, as this Gram-positive bacterium has evolved elaborate molecular strategies to subvert host cell functions. LLO is a major virulence factor originally shown to be crucial for bacterial escape from the internalization vacuole after entry into cells
Authors
ali moayed
Biotechnology department, Imam khomeini International University, Qazvin, Iran
ramin hosseini
Biotechnology department, Imam khomeini International University, Qazvin, Iran