An Efficient One-Pot Synthesis of 1H-Pyrazolo[1,2-b]phthalazine-5,10-dione Derivatives using MCM-41

Aza heterocyclic compounds are major interest for organic chemists because of their mainly pharmacological activities and clinical applications such as antianxiety, antitumor, anticonvulsant, cardiotonic and vasorelaxant. This work a new and efficient synthesis of phthalazine drivatives from the three-component condensation reaction of malononitrile, phthalhydrazide and aromatic aldehydes using MCM-41 as catalyst. The features of this procedure are mild reaction conditions, good to excellent yields, short reaction times and operational simplicity.

Keywords:

MCM-41 , Phthalazine , Malononitrile , Multi Component , Aza Hetrocyclic