DFT calculations of adsorption of two anticancer drugs for drug delivery purposes: carboplatin and picoplatin

We perform the adsorption of two anticancer drugs used in chemotherapy to deliver these drugs safety to the target cells. Adsorption of carboplatin and picoplatin on the surface was successfully evaluated by density functional theory calculation (DFT). It was found that the chemical adsorption is the type of one between drug and the surface, based on the calculated values.Chemical adsorption which will not result in a strong interaction between drug and the surface is the best type of adsorption to release the anticancer drugs near the cancer cells. Based on the obtained data it was proved that adsorption of carboplatin and picoplatin has a promising result to serve in drug delivery systems in order to overcome side effects of the anticancer drugs.

Keywords:

adsorption , DFT calculation , carboplatin , picoplatin , drug delivery