Human sperm DNA damage in the context of assisted reproductive techniques
Publish Year: 1386
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJRM-5-2_002
تاریخ نمایه سازی: 16 شهریور 1395
Abstract:
Fertilization involves direct interaction of the sperm and oocyte, fusion of the cell membranes and union of male and female gamete genomes. The completion of this process and subsequent embryo development depend in part on the inherent integrity of the sperm DNA. Sperm genome quality has been emphasized for several years as playing a major role in early embryogenesis. There is clinical evidence showing that human sperm DNA damage may adversely affect reproductive outcomes and that spermatozoa of infertile men possess substantially more DNA damage than dospermatozoa of fertile men. Testing DNA integrity may help selecting spermatozoa with intact DNA or with the least amount of DNA damage for use in assisted reproductive techniques (ARTs). This review will focus on how sperm DNA is organized, what causes sperm DNA damage and what impact this damage may have on reproductive outcome.
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Authors
Mohamed Youssry
Department of Obstetrics and Gynecology, University of Alexandria, Alexandria, Egypt Department of Obstetrics and Gynecology, University of Schleswig – Holstein, Luebeck, Germany.
Batuhan Ozmen
Department of Obstetrics and Gynecology, University of Ankara, Ankara, Turkey. Department of Obstetrics and Gynecology, University of Schleswig – Holstein, Luebeck, Germany.
Yasser Orief
Department of Obstetrics and Gynecology, University of Alexandria, Alexandria, Egypt.
Khaled Zohni
Medical Sciences Division, Reproduction Unit, National Research Center, Egypt.