The effect of metyrosine/prednisolone combination to oophorectomy-induced osteoporosis
Publish Year: 1391
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJRM-10-4_011
تاریخ نمایه سازی: 16 شهریور 1395
Abstract:
Background: Osteoporosis is a chronic disease characterized by a decrease in bone mineral density (BMD) and corruption of the microarchitectural structure of bone tissue. Objective: It was investigated whether methylprednisolone had a favorable effect on osteoporotic bone tissue in Oophorectomy induced osteoporotic rats whose endogenous adrenaline levels are suppressed with metyrosine. Materials and Methods: Bone Mineral Density, number of osteoblast-osteoclast, bone osteocalcin levels and alkaline phosphatase (ALP) measurements were performed. Obtained results were compared with that of alendronate. Results: Oophorectomy induced osteoporosis was exacerbated by methylprednisolone. Alentronate prevented ovariectomised induced osteoporosis, but it couldn’t prevent methylprednisolone +ovariectomised induced osteoporosis in rats. Conclusion: Combined treatment with methylprednisolon and metyrosine was the best treatment for preventing osteoporosis but metyrosine alone couldn’t prevent osteoporosis in ovariectomised rats
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Authors
Suleyman Salman
Department of Obstetrics and Gynecology, Igdir National Hospital, Igdir, Turkey
Serkan Kumbasar
Department of Obstetrics and Gynecology, Igdir National Hospital, Igdir, Turkey
Ahmet Hacimuftuoglu
Department of Pharmacology, Ataturk University, Medical Faculty, Erzurum, Turkey
Berna Ozturk
Department of Pharmacology, Ataturk University, Medical Faculty, Erzurum, Turkey