The effect of metyrosine/prednisolone combination to oophorectomy-induced osteoporosis

Publish Year: 1391
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJRM-10-4_011

تاریخ نمایه سازی: 16 شهریور 1395

Abstract:

Background: Osteoporosis is a chronic disease characterized by a decrease in bone mineral density (BMD) and corruption of the microarchitectural structure of bone tissue. Objective: It was investigated whether methylprednisolone had a favorable effect on osteoporotic bone tissue in Oophorectomy induced osteoporotic rats whose endogenous adrenaline levels are suppressed with metyrosine. Materials and Methods: Bone Mineral Density, number of osteoblast-osteoclast, bone osteocalcin levels and alkaline phosphatase (ALP) measurements were performed. Obtained results were compared with that of alendronate. Results: Oophorectomy induced osteoporosis was exacerbated by methylprednisolone. Alentronate prevented ovariectomised induced osteoporosis, but it couldn’t prevent methylprednisolone +ovariectomised induced osteoporosis in rats. Conclusion: Combined treatment with methylprednisolon and metyrosine was the best treatment for preventing osteoporosis but metyrosine alone couldn’t prevent osteoporosis in ovariectomised rats

Authors

Suleyman Salman

Department of Obstetrics and Gynecology, Igdir National Hospital, Igdir, Turkey

Serkan Kumbasar

Department of Obstetrics and Gynecology, Igdir National Hospital, Igdir, Turkey

Ahmet Hacimuftuoglu

Department of Pharmacology, Ataturk University, Medical Faculty, Erzurum, Turkey

Berna Ozturk

Department of Pharmacology, Ataturk University, Medical Faculty, Erzurum, Turkey