Suleyman Salman - Department of Obstetrics and Gynecology, Igdir National Hospital, Igdir, Turkey
Serkan Kumbasar - Department of Obstetrics and Gynecology, Igdir National Hospital, Igdir, Turkey
Ahmet Hacimuftuoglu - Department of Pharmacology, Ataturk University, Medical Faculty, Erzurum, Turkey
Berna Ozturk - Department of Pharmacology, Ataturk University, Medical Faculty, Erzurum, Turkey

Background: Osteoporosis is a chronic disease characterized by a decrease in bone mineral density (BMD) and corruption of the microarchitectural structure of bone tissue. Objective: It was investigated whether methylprednisolone had a favorable effect on osteoporotic bone tissue in Oophorectomy induced osteoporotic rats whose endogenous adrenaline levels are suppressed with metyrosine. Materials and Methods: Bone Mineral Density, number of osteoblast-osteoclast, bone osteocalcin levels and alkaline phosphatase (ALP) measurements were performed. Obtained results were compared with that of alendronate. Results: Oophorectomy induced osteoporosis was exacerbated by methylprednisolone. Alentronate prevented ovariectomised induced osteoporosis, but it couldn’t prevent methylprednisolone +ovariectomised induced osteoporosis in rats. Conclusion: Combined treatment with methylprednisolon and metyrosine was the best treatment for preventing osteoporosis but metyrosine alone couldn’t prevent osteoporosis in ovariectomised rats

Osteoporosis, Metyrosine, Methylprednisolon, Alendronate, Ovariectomy