Investigation on estrogen receptor alpha gene polymorphisms in Iranian women with recurrent pregnancy loss

Publish Year: 1393
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJRM-12-6_004

تاریخ نمایه سازی: 16 شهریور 1395

Abstract:

Background: Recurrent pregnancy loss (RPL) is a multifactorial disorder. Environmental factors and genetics can affect pregnancy outcomes.Objective: Conflicting data suggest an association between estrogen receptor alpha (ESR1) gene polymorphisms and RPL. In this study, such association was investigated in Iranian women with RPL.Materials and Methods: In this case control study, blood samples were collected from 244 women with a history of three or more consecutive pregnancy losses and 104 healthy women with at least two live births. Using polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP), we studied -397C/T and -351A/G polymorphisms on ESR1 gene in case and control subjects.Results: The genotypic frequencies of -397C/T and -351A/G polymorphisms on ESR1were not significantly different between RPL and control groups (p=0.20 and p=0.09, respectively). A significantly negative correlation was observed between -397C/T and -351A/G (r=-0.852, p<0.001) in RPL women and complete linkage disequilibrium between the investigated polymorphisms was found (D’: 0.959; r-square= 0.758, p<0.001).Conclusion: This investigation suggests that the analyzed polymorphisms on ESR1gene are not associated with an increased risk of RPL in the studied population.

Authors

Marzieh Mahdavipour

Cell and Molecular Research Centre, Qazvin University of Medical Sciences, Qazvin, Iran..Reproductive Immunology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

Farah Idali

Reproductive Immunology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

Saeed Zarei

Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Saeed Talebi

Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran