Seddigheh Esmaeilzadeh - Fatemeh-zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran
Parvaneh Mirabi - Fatemeh-zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran
Zahra Basirat - Fatemeh-zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran
Mahtab Zeinalzadeh - Fatemeh-zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran

Background: The association of endometriosis with hyperprolactinemia is controversial. Objective: The present study aimed to determine the frequency of endometriosisand association of prolactin with endometriosis in infertile women. Materials and Methods: 256 infertile women who underwent diagnosticlaparoscopy for the evaluation of infertility, referred to Fatemezahra Infertility and Reproductive Health Research Center were included in a cross-sectional study. Thepresence of endometriosis was evaluated. To investigate the association of endometriosis with hyperprolactinemia, the patients whose infertility was not causedby endometriosis were included as control group. Serum prolactin (PRL) level was measured in both groups. The comparison of basal serum PRL levels between the two groups was performed, using independent t-test. One way ANOVA was used todetermine PRL association with endometriosis stages. Results: The frequency of endometriosis was found to be 29%. PRL levels weresignificantly higher in endometriosis group compared to control group (23.02±1.25 vs. 17.22±1.22 respectively, p=0.004). Statistically significant associations werefound between staging of endometriosis and prolactin levels (p=0.01). Conclusion: Hyperprolactinemia may be associated with endometriosis and its progression

Endometriosis, Infertility, Hyperprolactinemia, Laparoscopy