IN VITRO RELEASE BEHAVIOR AND EX VIVO EVALUATION OF QUERCETIN-MICROEMULSIONS FOR TOPICAL DELIVERY
عنوان مقاله: IN VITRO RELEASE BEHAVIOR AND EX VIVO EVALUATION OF QUERCETIN-MICROEMULSIONS FOR TOPICAL DELIVERY
شناسه ملی مقاله: TCPCO03_143
منتشر شده در سومین همایش ملی تکنولوژی های نوین در شیمی،پتروشیمی و نانو ایران در سال 1395
شناسه ملی مقاله: TCPCO03_143
منتشر شده در سومین همایش ملی تکنولوژی های نوین در شیمی،پتروشیمی و نانو ایران در سال 1395
مشخصات نویسندگان مقاله:
A Kajbafvala - Departmant of Chemistry, Faculty of Science, Arak University
A Salabat - Departmant of Chemistry, Faculty of Science, Arak University
خلاصه مقاله:
A Kajbafvala - Departmant of Chemistry, Faculty of Science, Arak University
A Salabat - Departmant of Chemistry, Faculty of Science, Arak University
This work was aimed for developing release behaviour, release kinetics and mechanisms as well as evaluation of ex vivo drug penetration for delivery of the anti-oxidant drug named quercetin encapsulated in microemulsion formulations composed of Tween 80 as surfactant, Transcutol® P as co-surfactant, oleic acid as oil phase and water as aqueous phase. The obtained results showed a slow release behavior without any transdermal delivery. Most of the formulations fitted best with zero-order kinetics and had non-Fickian dissolution mechanisms that could be worthwhile for topical administrations. This study illustrated that the proposed QU-microemulsion formulation has a good potential for use in sunscreen formulations
کلمات کلیدی: Quercetin, Microemulsion, Release, Kinetic, topical delivery
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/490975/