Publisher of Iranian Journals and Conference Proceedings

Please waite ..
CIVILICAWe Respect the Science
Publisher of Iranian Journals and Conference Proceedings
عنوان
Paper

Computational Investigation of Hsa-mir-196a-2 Targetome Pathway and its SNP Function in Patientswith Gastric Carcinoma: Probable Association Between Alleles and Patients Prognosis

تعداد صفحات: 1 | تعداد نمایش خلاصه: 400 | نظرات: 0
سال انتشار: 1394
کد COI Paper: NASTARANCANSER01_085
زبان Paper: Englishglish
متن کامل این Paper منتشر نشده است و فقط به صورت چکیده یا چکیده مبسوط در پایگاه موجود می باشد.
توضیح: معمولا کلیه مقالاتی که کمتر از ۵ صفحه باشند در پایگاه سیویلیکا اصل Paper (فول تکست) محسوب نمی شوند و فقط کاربران عضو بدون کسر اعتبار می توانند فایل آنها را دریافت نمایند.

مشخصات نویسندگان Paper Computational Investigation of Hsa-mir-196a-2 Targetome Pathway and its SNP Function in Patientswith Gastric Carcinoma: Probable Association Between Alleles and Patients Prognosis

Narges Tabatabaie - Division of Cellular and Molecular Biology, Department of Biology, Nourdanesh University of Meymeh, Meymeh, Isfahan, Iran
Hamzeh Mesrian Tanha - Division of Cellular and Molecular Biology, Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran
Kamran Ghaedi - Zistfanavari Novin Biotechnology Institute, Isfahan, Iran
Mansoureh Azadeh - Gastric Cancer, MicroRNA, SNP, Helicobacter Pylori, MiR-196a-2, Rs11614913

چکیده Paper:

Gastric cancer (GC) is the third most common cancer and the second leading cause ofcancer fatality worldwide. In 2012, about three quarters of novel GCs happened in Asia.Helicobacter pylori infection is an important risk factor for GC. MicroRNAs (miRNAs) aresmall noncoding RNAs that work as post-transcriptional regularizers of gene expression andinvolve in various cancers. Single nucleotide polymorphisms (SNPs) which are located inmiRNAs locus may affect either expression or function of miRNAs. The miR-196a-2polymorphism rs11614913 is related to the susceptibility of diverse tumors, including gastriccancer.This study aimed to expand current knowledge about molecular function of miR-196a-2 and its SNP in GC cells as a prognostic biomarker in GC patients. MiRNASNP databaseillustrates SNP in miR-196a-2. MiRBase database gives general information about miR- 196a-2. Predicted targets of miR-196a-2 were obtained from miRWalk database. Targetomeexpression in GC was evaluated in UniGene database. Finally, DAVID database was usedfor molecular pathways enrichment analysis. It is predicted that miR-196a-2 functions as acrucial tumor suppressor by inhibiting some significant genes in epithelial cell signaling inHelicobacter pylori infection such as PAK1, JNK, IκBα that these genes play a vital role inchemotactic effect. Chemotactic activity quickly increases Helicobacter pylori colonizationand infection. Furthermore, T allele causes the stability reduction of miR-196a-2 structure.Subsequently, there is a probable connection between T allele and poor prognosis of GC. Inother words, rs11614913 may contribute to increase Helicobacter pylori infection and GCsusceptibility due to alteration of epithelial cell signaling. According to our data, miR-196a-2and its SNP may be involved in GC and its prognosis by altering regulation of epithelial cellsignaling in Helicobacter pylori infection and some key signaling pathways. Shortly, T allelein this position can have prognostic value for GC.

کد Paper/لینک ثابت به این Paper

برای لینک دهی به این Paper می توانید از لینک زیر استفاده نمایید. این لینک همیشه ثابت است و به عنوان سند ثبت Paper در مرجع سیویلیکا مورد استفاده قرار میگیرد:

https://civilica.com/doc/513701/

کد COI Paper: NASTARANCANSER01_085

نحوه استناد به Paper:

در صورتی که می خواهید در اثر پژوهشی خود به این Paper ارجاع دهید، به سادگی می توانید از عبارت زیر در بخش منابع و مراجع استفاده نمایید:
undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined,1394,Computational Investigation of Hsa-mir-196a-2 Targetome Pathway and its SNP Function in Patientswith Gastric Carcinoma: Probable Association Between Alleles and Patients Prognosis,اولین سمپوزیوم بین المللی سرطان نسترن,Mashhad,,,https://civilica.com/doc/513701

در داخل متن نیز هر جا که به عبارت و یا دستاوردی از این Paper اشاره شود پس از ذکر مطلب، در داخل پارانتز، مشخصات زیر نوشته می شود.
برای بار اول: (1394, Tabatabaie, Narges؛ Hamzeh Mesrian Tanha و Kamran Ghaedi و Mansoureh Azadeh)
برای بار دوم به بعد: (1394, Tabatabaie؛ Mesrian Tanha و Ghaedi و Azadeh)
برای آشنایی کامل با نحوه مرجع نویسی لطفا بخش راهنمای سیویلیکا (مرجع دهی) را ملاحظه نمایید.

Research Info Management

Certificate | Report Paper

Export Citation info of this Paper to research management softwares

New RelatedPapers

Share this paper

WHAT IS COI?

COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.

Support