Synthesis of ethyl 7-(4-chlorophenyl)-3-hydroxy-5-methyl-3-phenyl-2,3-dihydro-7H-thiazolo[3,2-a]pyrimidine-6-carboxylate in aquence Ionic liquid

Biginelli reaction of ethyl acetoacetate, thiourea and the appropriate aromatic aldehyd was used to produce ethyl 4-(4-chlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate,that reacted with 2-bromo acetophenone in an ionic liquid as a green solvent to give ethyl 7-(4-chlorophenyl)-3-hydroxy-5-methyl-3-phenyl-2,3-dihydro-7H-thiazolo[3,2-a]pyrimidine-6-carboxylate. The used ionic liquid in this work was1-methyl-3-pentylimidazolium bromide.The ionic liquid has been used as a solvent as well as catalyst for this reaction.

Keywords:

ionic liquid , pyrimidine , α-bromoketone , thiazole , green solvent