Farzaneh Mohamadpour - Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran
Malek Taher Maghsoodlou
Reza Heydari

An efficient and simple synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives via one-pot four- component condensation reaction of phthalimide, hydrazine monohydrate, aromatic aldehydes derivatives and malononitrile in the present of a catalytic amount of CdCl2.H2O as a mild and efficient catalyst under thermal and solvent-free conditions with excellent yields and short reaction times is reported. This present methodology has notable benefits such as highly efficient, high catalytic activity, inexpensive and non-toxic catalyst, one-pot, environmentally benign nature, solvent-free conditions, simplicity of operation, eco-friendly.

CdCl2.H2O, 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives, solvent-free conditions, Multi-component reaction, Efficient catalyst