Anti-tomur and antimicrobial activities of Nano derivatives from four plant groups and study their characterizations

Introduction: Anticancer drugs have originated from a variety of sources, including dyestuffs and chemical warfare agents, and from natural products such as plants, microbes and fungi. Natural compounds as an anticancer and antibacterial agents, used for synthesis of metal complexes because the biological activity of these compounds are believed to increase when they are coordinated with transition metal ions. Materials and methods: In this study, metal complexes of natural compounds have been prepared and characterized by elemental analysis, 1H-NMR, IR, Raman and UV-visible spectroscopy also metal complex nanoparticles were prepared by the ultrasonic method and characterized by SEM, XRD. All plant extracts (Phytochemical Samples) were purchased from Merk and were used without further purification. Results: The data suggest that these new complexes have excellent antitumor activity against two kinds of cancer cells: AGS (Stomach) and MCF-7 (Breast) cells. Also, these complexes were tested for their antibacterial activity against Staphylococcus aureus, Streptococospyogenes, Escherichia coli, Pseudomonas aeruginosa comparatively with that of free ligand. No inhibition zone was seen in Thymol complex (Nano scale) and Thannic acid ligand, reflecting no antibacterial activity for these materials. Caffeic acid complex (Normal scale) against E coli and Thymol ligand against Pseudomonas aeruginosa were more effective with 14 mm as zone of inhibition. Conclusion: According to our results, metal complexes of 4 plant groups could be used as raw materials for phytotherapy because of their antibacterial activities.

Keywords:

Natural compounds , Co (II) complex , Anticancer activity , Antibacterial activity , Nanoparticles