Impact of Sargassum Tenerrimum algae extract on the calcium rate of femur and L5 lumbar vertebrae by atomic absorption technique in mice with osteoporosis

Publish Year: 1395
نوع سند: مقاله کنفرانسی
زبان: English
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MPHBS01_076

تاریخ نمایه سازی: 22 آبان 1395

Abstract:

Introduction: According to the latest investigations doing by researchers on osteoporosis medication, side effects such as osteonecrosis of the jaw, atrial fibrillation, esophageal cancer, atypical femoral fractures, nowadays the use of natural materials has received more attention. Materials and methods: In this study, 80 NMRI mice were randomly divided into three groups as: Control, sham and ovariectomy (OVX); and then the OVX group was induced osteoporosis through ovariectomy and injection corticosteroids. After confirming the disease induction by the histopathological method, OVX group was divided into three groups: positive control, experimental, and negative control. Therapeutic dose in the positive control group was 125 mg/Kg/day calcium carbonate and 0.025 μg/week/mice of vitamin D, and in the experimental group sargassum tenerrimum algae extract by a dose of 10 mg/ml/100g, which was conducted in both groups for 28 days through gavage method. Having euthanized mice at week 24, atomic absorption technique of calcium was performed on L5 lumber vertebrae and femur. Results: The rate of bone calcium in the experimental group was significantly more than that in the negative control group (P<0.05), and no significant change was observed in weight and length of bone compared to the negative control group (P<0.05). Conclusion: The findings suggest that Sargassum tenerrimum algae may result in increased bone formation and bring anabolic effects on the improvement of the disease through increasing the rate of bone calcium like what Yamaguchi and Ushiama (2002) reported.

Authors

Azadeh Sadat Javadi

Department of biology, Islamic Azad University Of Parand, Tehran, Iran.

Mitra Heydari Nasr Abadi

Department of biology, Islamic Azad University Of Central Tehran Branch, Tehran, Iran.

Gholamreza Bakhshi Khaniki

Department of biology, Islamic Azad University Of Parand, Tehran, Iran.