The effect of cholesterol lowering drugs on vitamin D in people with family high blood cholesterol

Introduction: Family genetically high blood cholesterol is a common disease that involves many complications for patients. This study links cholesterol lowering drugs and serum levels of vitamin D have been investigated. Materials and methods: In this study, the 25-hydroxy vitamin D in 65 women 30-50 years of age, were evaluated by ELISA. After receiving drug information and ensure that the drugs lower cholesterol do not use, vitamin D and cholesterol were measured. After 9 months, cholesterol-lowering medication Gemfibrozil and Atorvastatin prescribed by a physician, vitamin D and cholesterol were measured. Also 30 persons during 9 months of taking the drug, vitamin D supplements regularly received. Moreover, the results between the two periods were statistically tested. Results: At first period, the level of cholesterol and vitamin D in the women, respectively, were measured high and normal. In the second phase, due to using prescription drugs, inhibit the synthesis of HMG-CoA reductase and blood cholesterol significantly decreased, but the amount of vitamin D also showed greatly reduced. Women who used vitamin D supplements, showed relatively low levels of vitamin D. Conclusion: Despite the decrease in cholesterol levels after taking the drug, vitamin D deficiency was seen. Despite taking the drug for patients genetically perpetuity, after long-term use osteoporosis can be predicted in these people. So taking supplements and foods rich of vitamin D during drug use is proposed

Keywords:

Vitamin D , High blood cholesterol , Osteoporosis , ELISA