Saeed Sorush - Medical Student in Gilan University of Medical Sciences, Gilan, Iran.
Mehrnaz Ajorloo - Genetic Engineering Student in Rudehen Azad University, Rudehen, Iran

Idiopathic infertility refers to a type of infertility that its physiological, anatomical and molecular causes are not found to justify it. In fact, when the initial visit parameters for infertile couples including sperm standards examination and spermatography analysis, structure of the reproductive organs such as openness of Fallopian tubes, lack of endometriosis as well asproper function of the ovaries and ovulation control were analyzed and the accuracy of these parameters was in accordance with the standards and when the planned fertility did not occur due to ovulation time, idiopathic infertility (infertility of unknown cause) is detected. Idiopathic infertility I is directly related to infertility genetics. Various genetic factors are involved in infertility idiopathic such as certain polymorphisms, and mutations in genes in sexual chromosomes. XRCC1 Gene Arg399 G/n is among important polymorphisms: 1. polymorphism in female infertility removed certain areas of the KISS1 in the receptor gene 155bp in Cron 148 and remove the piece of 2. Polymorphism, which ultimately leads to a kind of oligospermia (low number of sperm) and azoospermia (absence of sperm from the semen fluid) in Y chromosome. In the name of DF, the product Y reproduces genes on the short arm of SRY chromosome of the genes involved in the evolution and development of the reproductive organs. Determining factortestis produces DNA, which is a binding protein to DAX1, WT1, SF1, and SOX1. This genealong with other numerous genes controls the expression of genes involved in the development of testis. In the absence of the proper function of these genes,the early testes of embryo develop into ovarium. We conclude that in many infertility treatments, due to the interference of molecular and genetic mechanisms, it has not favorable effects, therefore, the analysis of infertility genetic factors should be the first stage of idiopathic infertility diagnosis.

Polymorphism, Genetic mutation, Idiopathic infertility, Sex genetics