Mozhgan Elahdadi - Department of Physiology of Exercise, Faculty of Physical Education, Shahrood University of Technology, Shahrood, Iran.
Ali Younesian - Department of Physiology of Exercise, Faculty of Physical Education, Shahrood University of Technology, Shahrood, Iran.

Introduction: Among sedentary subjects with high BMI and WHR, there are many cardiometabolic risk factors. Regular exercise has a protective effect on cardiovascular and all-cause mortality. Exercise makes white adipose tissue to brown adipose tissue. Irisin as a new Myokine seems to have a role in making white adipose tissue to brown. So we are investigating the effect of eight weeks resistance exercise on serum Irisin level and it's relation to cardiovascular risk factors in prediabetic women. Materials and methods: Sedentary subjects with a high BIM and WHR voluntarily participated in this study. Subjects divided randomly into two, control (9) and experiment (11) group. They take part in eight weeks resistance exercise with 65% to 80% of 1RM. Blood samples were taken before and after exercise and analyzed in the laboratory. Cardiometabolic risk factors include fasting blood sugar (FBS), triglyceride (TG), high lipoprotein density (HDL), systolic blood pressure (SBP) and diastolic blood pressure. Statistical analysis of the data was done by IBM SPSS Statistic 22 software. The data statistically analyzed using paired sample T test. Results: Irisin and cardiometabolic risk factors (0/05>p) reduced significantly in respect to eight weeks resistance exercise in prediabetic women. But there were no significant relationship between Irisin and cardiometabolic risk factors. SBP did not change significantly. Conclusion: We conclude eight weeks resistance exercise has an effective result in reducing cardiometabolic risk factors but not in reducing systolic blood pressure. Irisin was reduced in respect to resistance exercise, too. There were no relation between Irisin and cardiometabolic risk factors in this study.

Irisin, Cardiovascular risk factor, Resistance exercise