Effects of forced exercise on mechanical allodynia in a rat model of chronic constriction injury

Publish Year: 1395
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

MPHBS01_195

تاریخ نمایه سازی: 22 آبان 1395

Abstract:

Introduction: Neuropathic pain is caused by damage or disease of the nervous system that affects the structure and functioning of the somatosensory system. This study was designed to investigate the effects of exercise on neuropathic pain behavior and serum level of Ferric reducing antioxidant power (FRAP) and malondialdehyde (MDA) induced by chronic constriction injury (CCI) in rats. Materials and methods: Adult male Wistar rats (200 to 250 g) were randomly assigned into 5 groups: Intact, Sham, CCI, Pre CCI exercise and post CCI exercise. CCI was induced by applying 4 loose ligatures around the sciatica nerve. Animals run on treadmill for 3 weeks. Mechanical allodynia (von Frey filament testing) and serum level of FRAP and MDA measured in 21th days after CCI. Data were analyzed by one-way ANOVA followed by Tukey’s multiple comparison post hoc tests. P values less than 0.05 were considered significant. All data are expressed as mean ± SEM. Results: The CCI group showed a significant increase in mechanical allodynia compared with sham and Intact groups (P<0.05). Mechanical allodynia significantly (P<0.01) decreased in post CCI exercise group compared to cci. FRAP significantly (P<0.01) decreased in CCI group respect to sham group, however, it increased (P<0.05) in post CCI exercise group compared to CCI group. Serum MDA level was not different between groups. Conclusion: These findings indicate that moderate forced exercise reduces theneuropathic pain in a rat model of CCI probably via change in Ferric reducing antioxidant power

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Authors

Ali Ghanbari

Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran.

Nasroallah Moradi Kor

Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran.

Atiyeh Bazargani

Student Research Committee, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.

Ahmad Reza Bandegi

Department of Biochemistry, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.