Magnetic nanocarrier coated by long polymeric spacer, highlystable for controlled delivery of doxorubicin

Publish Year: 1395
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

CHECONF03_129

تاریخ نمایه سازی: 14 آذر 1395

Abstract:

A novel magnetic nanocarrier with long spacer length and high colloidal stability has been prepared for effective delivery of doxorubicin (DOX). First, poly(amidoamine) (PAMAM) dendrimer was grownup onto the surface of superparamagnetic iron oxide nanoparticles to increase the loading amount of amine groups. Then, terminal amine groups were functionalized by polyethylene glycol dimethylesterto increase the spacer length. Then anticancer drug DOX was covalently attached onto the system by hydrazone bond to forms a pH-sensitive nanocarrier. This system is designed to combine the advantage of magnetic targeting, high drug loading capacity, and controlled release.

Authors

Niloofar Niloofar

Polymer Research Laboratory, Department of Chemistry, Sharif University of Technology, Tehran, Iran