Synthesis of Substituted 4-Hydroxyquinoline-2(1H)-ones andSome of Their Novel Derivatives

6-Chloro and 6-fluoro-4-hydroxy quinoline-2(1H)-one were synthesized by cyclocondensation reaction of corresponding N, Nʹ-di aryl malonamide by means of polyphosphoric acid. These compounds were applied as a main scaffold for the preparation of some novel derivatives. The structures of the compounds were confirmed by infra-red and NMR spectroscopy

Keywords:

4-hydroxy quinoline-2(1H)-one , Polyphosphoric acid , quinolone