Farzaneh Mohamadpour - Department of Chemisty, Faculty of Science, University of Sistan and Baluchestan. P.O.Box 98135-674 Zahedan, Iran
Malek Taber Maghsoodlou - Department of Chemisty, Faculty of Science, University of Sistan and Baluchestan. P.O.Box 98135-674 Zahedan, Iran
Reza Heydari - Department of Chemisty, Faculty of Science, University of Sistan and Baluchestan. P.O.Box 98135-674 Zahedan, Iran

In this protocol, we have reported Nano Zeolite as an efficient and environmentally benign nature catalyst for the one-pot three-component Biginelli synthesis of 3,4-dihydropyrimidin-2- (1H)-ones derivatives via β-keto esters, aldehyde derivatives and urea/thiourea under thermal and solvent-free conditions with short reaction times and excellent yields. The most benefits this procedure is such as inexpensive and non-toxic catalyst, eco-friendly, solvent-free conditions, simple poerational procedures, environmentally benign nature, one-pot, excellent yields.

Nano Zeolite,, 3, 4-Dihydropyrimidinone, Biginelli, reaction