Nano Ni: As an efficient and environmentally benign nature catalyst assisted one- pot four-component synthesis of substituted dihydro-2-oxypyrroles

In this protocol, we have reported an efficient, simple and environmentally benign nature methodology for the synthesis of substituted dihydro-2-oxypyrrole via a one-pot four-component domino condensation of dialkyl acetylenedicarboxylate, formaldehyde and amines (aromatic and aliphatic) under ambient temperature with excellent yields and short reaction times. Nano Zeolite has been used as a mild, economical and environmentally friendly catalyst for preparation of substituted dihydro-2-oxypyrrole. The environmentally benign nature, simple, inexpensive and non-toxic catalyst, easily separated with no column chromatographic separation, high catalytic activity, highly efficient is an option for the simple synthesis of these rings.

Keywords:

Nano Zeolite , Dihydro-2-oxypyrrole derivatives , Multi-component reaction , Efficient methodology