Farzaneh Mohamadpour - Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan,Iran
Malek Taher Taher Maghsoodlou - Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan,Iran
Reza Heydari - Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan,Iran

In this protocol, we have reported an efficient and simple synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives via one-pot four- component condensation reaction of phthalimide, hydrazine monohydrate, aromatic aldehydes derivatives and malononitrile in the prosent of a catalytic amount of Nano Ni as a mild and efficient catalyst under thermal and solvent-free conditions with excellent yields and short reaction times. This present methodology has notalble benefits such as highly efficient, high catalyic activity, inexpensive and non-toxic catalyst, one-pot, environmentally beinign, solvent-free conditions, simplicity of operation, eco-friendly.

Nano Ni, 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives, solvent-free