Growth factor Containing Hydrogels for Tissue Engineering Applications

Publish Year: 1393
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_JABR-1-3_001

تاریخ نمایه سازی: 29 آذر 1395

Abstract:

Regenerative medicine provides substitutes for organ transplantation, which is restricted in applicability due to immune responses against allograft and the largediscrepancy between the need for organs and the number of available transplantation. An artificial environment is allowing cells to induce tissueregeneration. Growth factors (GFs) play a significant role in the cell fates in their microenvironment. Nevertheless, the short half-lives of GFs and poor in vivostability infiltration suggest that the classical routes are useless and insist on use of a drug delivery system (DDS). In this review paper, growth factor-based tissueregeneration using polymeric hydrogels is reviewed to show great potential ability of hydrogels in tissue engineering (TE).

Authors

Hamid Babavalian

Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Ali Mohammad Latifi

Applied Biotechnology Research Center,Baqiyatallah University of Medical Sciences, Tehran, Iran

Mohammad Majid Sepantafar

Department of Stem Cells and Developmental Biology at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran . Department of Metallurgy and Materials Engineering, Faculty of Engineering, University of Semna

Hossein Mohammadi

Department of biomaterials, Science and Research Branch, Islamic Azad University, Yazd, Iran