Hamid Babavalian - Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Ali Mohammad Latifi - Applied Biotechnology Research Center,Baqiyatallah University of Medical Sciences, Tehran, Iran
Mohammad Majid Sepantafar - Department of Stem Cells and Developmental Biology at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran . Department of Metallurgy and Materials Engineering, Faculty of Engineering, University of Semna
Hossein Mohammadi - Department of biomaterials, Science and Research Branch, Islamic Azad University, Yazd, Iran

Regenerative medicine provides substitutes for organ transplantation, which is restricted in applicability due to immune responses against allograft and the largediscrepancy between the need for organs and the number of available transplantation. An artificial environment is allowing cells to induce tissueregeneration. Growth factors (GFs) play a significant role in the cell fates in their microenvironment. Nevertheless, the short half-lives of GFs and poor in vivostability infiltration suggest that the classical routes are useless and insist on use of a drug delivery system (DDS). In this review paper, growth factor-based tissueregeneration using polymeric hydrogels is reviewed to show great potential ability of hydrogels in tissue engineering (TE).

Hydrogel, Growth Factor, Tissue Engineering, Controlled Release