Safar Ali Ahmadizad Firozjaei - Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Biotechnology Center of Semnan University, Semnan, Iran
Ali Mohammad Latifi - Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Samaneh Khodi - Applied Biotechnology Research Center,Baqiyatallah University of Medical Sciences, Tehran, Iran
Shamsozzoha Abolmaali - Biotechnology Center of Semnan University, Semnan, Iran

Daily, organophosphorus compounds (OPs) in human life, has found wide applications. Although OPs have biodegradability potential, they induce clinicalproblems in humans and other organism. Different methods are used to detoxify these compounds. In the meantime, biodegradation is preferred as a compatibleway to the environment since it produces less toxic compounds. Enzymes capable to degrade the OPs are of the most important items in the biodegradation. Geneticmanipulation involved in the production of these enzymes has been employed in bacteria, and finally, is used for the mass production of recombinant microorganisms. In this paper, the role of organophosphates on human life and theways to destroy toxic organophosphates are studied.

Organophosphates Toxicity, Biodegradation, Hydrolysis Enzyme