Peyman Zargari - Department of Biology, Science and Research branch, Islamic Azad University, Tehran, Iran
Mohammad R. Ghasemi - Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Maryam Pirhoushiaran - Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Veda Vakili - Department of community medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Stroke is the leading cause of death and disability in the world after the cancer and cardiovascular diseases. Genetic factors are the main players to get stroke. Renin-angiotensin system contains candidate genes and polymorphismsfor causing stroke. There are reported associations between stroke and angiotensin II type -1 receptor g. 1166A > Cpolymorphism (rs5186). Therefore in this study this association was investigated for the east Iranian population.This study is based on 201 stroke patients and 220 controls. To predict the genetic risk of stroke allele and genotype frequencies of angiotensin II type-1 receptor rs5186 were analyzed in this population according to stroke subtypes, gender, age, hypertension, diabetes mellitus, high and low density lipoprotein and triglycerides. According to statistical analysis no significant difference was found between case and control groups. But there were asignificant relevance between total cholesterol and stroke (p = 0.037). In this population angiotensin II type-1receptor g. 1166A > C polymorphism did not increase the risk of stroke. The main reason for this study is complex nature of gene-environment interactions in the pathophysiology of this disease

Stroke, Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP),Angiotensin II type-1 Receptor g. 1166A > C Polymorphism