Afeefa Kiran Ch - Institute of Molecular Biology &. Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan
Muhammad Azam - Institute of Molecular Biology &. Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan
Arif malik - Institute of Molecular Biology &. Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan
kalsoom fatima - Institute of Molecular Biology &. Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan

Diabetes is one of the alarming health problem in Pakistan. According to international diabetes federation (IDF), about 7 million Pakistanis are victims of diabetes accounting a total of 3% population. Most of Pakistanis still preferto use herbal medicines for almost all of their health issues. Aegle marmelos (commonly known as the bael tree) ishighly reputed ayurvedic medicinal tree as it has been used in traditional medicine for centuries. In this pre-clinical work, 32 mice were induced for diabetes via injecting alloxan intraperitoneally at a dose of 100 mg/kg body weightand mice having 104-170 mg/dl sugar level were considered diabetic. All mice were divided into two groups, each group with three sub-groups containing normal, control and diabetic mice. One group was given normal feed whereasother group was given a food containing Aegle marmelos leaf extract at 300 mg/kg body weight as an effective dose against alloxan induced hyperglycemia. The experiments lasted for 60 days and blood samples (05 ml to 1.0 ml) werecollected from coccygeal vein of rats on 1st day, 30th day and 60th day of the experiment in heparinized tubes andblood glucose level was measured using spectrophotometer by enzymatic kit at a wavelength of 540nm. It was observed that the Aegle marmelos leaf extract is an effective herbal remedy in reducing and maintaining the glucose level in normal and hyperglycemic mice.

Diabetes mellitus, Aegle marmelos leaf, Hyperglycemia, Pre-clinical study