Design and Development of a Nanostructure Sensor for Determination of TBQ with MIP using Central Composite Design

Publish Year: 1394
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

ELECTROCHEMISTRY011_144

تاریخ نمایه سازی: 5 بهمن 1395

Abstract:

(TBHQ), a phenolic antioxidant used as a food additive, and its metabolite 2-tert-butyl-1,4- benzoquinone (TBQ) was cytotoxic in human monocytic leukemia U937 cells, TBQ being themore strongly cytotoxic. Both compounds induced caspase activity towards DEVD-MCA as a substrate and the cleavage of poly (ADP-ribose) polymerase in cells. The inhibition of monooxygenation activity was accompanied by redox cycling due to the tert-butylquinoneproduced during BHA metabolism, as measured by increased NADPH and oxygen consumption or hydrogen peroxide and superoxide anion production [1]. Accordingly, there is a need for a method to assess and determination of particular drug. Electrochemical sensor may serve thepurpose due to its relative simplicity, selectivity, low-cost and fast response time [2]. Molecularly imprinted polymer (MIP) were synthesized of TBQ (template), methacrylic acid as functional monomer, ethylene glycol dimethacrylate as cross-linking agent and 2,20- azobisisobutyronitrile as initiator . Then, the MIPs were used to modify the carbon paste electrode (CPE) [3].

Authors

Mehrnoosh Masoumi

Department of textile engineering, Science and Research Branch, Islamic Azad University, Yazd, Iran

Navid Nasirizadeh

Department of textile engineering, Science and Research Branch, Islamic Azad University, Yazd, Iran

Shahrzad Shojaee

Department of textile engineering, Science and Research Branch, Islamic Azad University, Yazd, Iran

Sanaz Akbarzadeh

Department of textile engineering, Science and Research Branch, Islamic Azad University, Yazd, Iran