Mehrnoosh Masoumi - Department of textile engineering, Science and Research Branch, Islamic Azad University, Yazd, Iran
Navid Nasirizadeh - Department of textile engineering, Science and Research Branch, Islamic Azad University, Yazd, Iran
Shahrzad Shojaee - Department of textile engineering, Science and Research Branch, Islamic Azad University, Yazd, Iran
Sanaz Akbarzadeh - Department of textile engineering, Science and Research Branch, Islamic Azad University, Yazd, Iran

(TBHQ), a phenolic antioxidant used as a food additive, and its metabolite 2-tert-butyl-1,4- benzoquinone (TBQ) was cytotoxic in human monocytic leukemia U937 cells, TBQ being themore strongly cytotoxic. Both compounds induced caspase activity towards DEVD-MCA as a substrate and the cleavage of poly (ADP-ribose) polymerase in cells. The inhibition of monooxygenation activity was accompanied by redox cycling due to the tert-butylquinoneproduced during BHA metabolism, as measured by increased NADPH and oxygen consumption or hydrogen peroxide and superoxide anion production [1]. Accordingly, there is a need for a method to assess and determination of particular drug. Electrochemical sensor may serve thepurpose due to its relative simplicity, selectivity, low-cost and fast response time [2]. Molecularly imprinted polymer (MIP) were synthesized of TBQ (template), methacrylic acid as functional monomer, ethylene glycol dimethacrylate as cross-linking agent and 2,20- azobisisobutyronitrile as initiator . Then, the MIPs were used to modify the carbon paste electrode (CPE) [3].

TBQ, Molecularly imprinted polymer, carbon paste electrode, cyclic voltammetry, differential pulse voltammetry