Antibiotics are one of the most important bioactive and chemotherapeutic groups of compounds made by microbiological synthesis.
Tetracycline (TC) or its derivatives such as chlorte-tracycline (Chlor-TC), oxytetracycline (Oxy-TC) and doxycycline (Doxy-TC) are employed extensively asbacteriostatic and antibiotic drugs. Several analytical methods have been reported for TCs antibiotic residues determination. Chromatographic methods are the most currently applieddespite they demand long and tedious extraction procedures, skilled personnel and are quite expensive. The Cyclodextrins (CD) have a truncated cone-resembled shape with a hollow cavity. The sizes of the primary and secondary sides of the CDs are dependent on the unit number ofglucose. The depth of the hollow cavity is 0.78 nm for all three types of CDs. Thus, a variety of guests can be encapsulated into the cavity via the host-guest interaction in aqueous conditionsand even in the solid state. On the other hand Graphene (Gr) has proved to be an excellentnanomaterial for applications in electrochemistry. because of its very large 2-D electrical conductivity, large surface area and low cost. In comparison with CNTs, two advantages of
graphene are apparent, as follows. Therefore β-Cyclodextrin functionalised
graphene is able simultaneously possessing unique properties of
graphene and β-Cyclodextrin. In this study fabricated modified glassy carbon electrode with β-yclodextrin functionalised
graphene (GC/Gr/β-CD) and applied for electrochemical measurement of TC. Cyclic voltammetry was employed to evaluate the electrochemical performance of
modified electrode and compare itselectrochemical performance with modified glassy carbon with
graphene (GC/Gr) and bareelectrode. As can be seen of fig (1) GC/Gr/β-CD is capable in TC oxidation than other two electrodes. After optimization all effective parameter in measurment such as pH, instrumental parameter we obtain calibration curve for TC determination By methods of differential pulse voltammetry (DPV) and linear sweep voltammetry (LSV) that shown in Fig (2) to (3). In Table (1) show the results obtain from calibration curves and Compared with other works. To examine the predominant type of mass transport a study was carried out using cyclic voltammetry on scan rate effect and the result shows electrooxidation reaction is an adsorption controlled process