Risperidone (RIS) (3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl] ethyl]-6,7,8,9- tetrahydro- 2-methyl 4H-pyrido[1,2-a] pyrimidin-4-one) is a benzisoxazole antipsychotagent,used to treat schizophrenia and other psychoses. It exerts its effect by blocking serotonin and dopamine receptors and causes a lower incidence of extrapyramidal side effects than standard neuroleptic drugs. It is effective in the treatment of schizophrenia and other psychiatric illnessesin adults and children including pervasive developmental disorders, autism and attention deficit disorder. For adequate support of clinical studies with RIS, an analytical method is required for the determination of plasma levels of RIS. It is necessary to establish a simple, accurate andspecific analytical technique, which permits measurements of RIS in biological specimens at different therapeutic levels [1]. Ionic liquids, given their favorable properties such as high conductivity, good chemical and electrochemical stability, and negligible volatility, are nowunder investigation for use in many electrochemical energy conversion devices [2]. Polymeric ionic liquids (PILs) are polymeric analogues of ionic liquids obtained via polymerization of ionic liquid monomers, mainly imidazolium based ionic liquid monomers. Being a novel polymericmaterial, PILs exhibit the advantages of both ionic liquids and polymers, such as enhanced ionic conductivity, thermal stability and excellent mechanical properties. Owing to their unique properties, PILs have attracted great interest in various fields. For example, PILs have beenproved to be effective stabilizer or modifier for the synthesis and functionalization of various nanomaterials, such as noble metal nanoparticles. With the modification of PILs, the assynthesizednanomaterials not only maintained their own properties, but also are endowed with improved conductivity, excellent hydrophilicity and positive charged [3]. In this study, a
glassy carbon electrode (GCE) modified with nanaocomposite of [Ni(CN)2(NH3] and poly[MImEO2BS] and nafion (NCPMNINGCE), was used to prepare a novel electrochemical sensor for the detection of RIS. Under the optimum pH, It has been found that the oxidation of
risperidone at the surface of modified electrode occurs at a potential of about 130 mV lesspositive than that of an unmodified carbon paste electrode. (SWV) exhibits linear dynamic range from 5.0×10-7 to 8.0×10-5 M and detection limits of 7.3×10-8 M for risperidone. The present method was applied to the determination of RIS in some real samples