Positively Charged Sulfonamide Carbon Nanoparticles /SDS Modified Carbon Paste Electrode: A Voltametric Sensor for Ciprofloxacin

Nano-carbon based electrodes e.g. based on carbon nanotubes, carbon nanofibers, graphene, or carbon nanoparticles are of interest in electrochemical processes due to their often highly activesurface characteristics and their ease of functionalisation. The modification of functional groupsat carbon surfaces provides an important tool for achieving chemical selectivity [1]. Ciprofloxacin is a second-generation fluoroquinolone employed for treatment of different kinds of bacterial infections in the body. An overdose of ciprofloxacin results in severe hepatotoxicity. Thus, there is a need to develop reliable, sensitive, simple and rapid method for the determination of CFX in pharmaceutical preparations and body fluids [2].In this study, the surface functionalities of commercial sulfonate-modified carbon nanoparticles have been converted from negatively charged to positively charge. To evaluate theelectrochemical sensing ability of the positively charged carbon nanoparticles, modification of carbon paste electrode has been performed by casting method. The modified electrode has been used for voltammetric measurements of Ciprofloxacin. Differential pulse voltammetry has beenapplied for sensitive determination of Ciprofloxacin in real samples. Methods Voltammetric experiments were performed using a Metrohm Computrace VoltammetricAnalyzer model 797 VA. A conventional three-electrode. To evaluate the electrochemical sensing ability of the CNP-NH3+ -SDS through Ciprofloxacin, modification of carbon paste electrode has been performed by casting method. 10 μL of CNPNH3+ suspension was casted on the CPE surface and dried in the air to evaporate solvent. SDS modified electrodes (denoted as CNP-NH3+-SDS electrodes) were prepared by soaking the CNPNH3 + modified electrode in SDS solution (8.0 mM) for 10 s immersion time. The modifiedelectrode has been used for voltammetric measurements.Result and Discussion Morphology and structure of the resultant product were characterized by SEM, FT-IRspectroscopy and electrochemical techniques (estimation of capacitive current, absorbed redox systems, Electrochemical Impedance Spectroscopy and cyclic voltametry). The affinity of CFX to adsorb CNP-NH3 +-SDS film at the carbon paste electrode is been studied in pure electrolyteafter pre-immersion of the electrode into CFX. Fig. 1 shows a considerable enhancement in the peak current using the CNP-NH3 +-SDS modified electrode obtained. Differential pulse voltammetry has been applied for sensitive determination of Ciprofloxacin in real samplesConclusionThe covalently modification of carbon nanoparticles with ethylene diamine functional groups isdemonstrated. The new carbon nanoparticle substrate is versatile and can be employed for sensitive and selective extraction of CFX. Enhanced voltammetric responses are observed for pre-adsorbed CFX at the surface of CPE/CNP-NH3 +-SDS electrode, high sensitivity with low levels of CFX are achieved

Keywords:

Carbon nanoparticle , SDS , Covalently modification , voltammetric sensor , Ciprofloxacin