Electrochemical Approach for Preconcentration and Determination of Anti Cancer Drug Capecitabine by a Novel Organic Solvent Mediated HF-PGE electrode

Capecitabine, chemically 5'-deoxy-5-fluoro-N4-pentyloxycarbonyl-cytidine [1], represents the first-line treatment for colorectal and breast cancers [2]. The aim of this study was to design anew sensitive single-use electrode to CPT preconcentration and measurment simultaneously for use in a three-electrode voltammetry system. This electrode was designed by modifing pencil graphite electrode with a new combination of functionalized polyurethane foam and MWCNTsupported by hallow fiber, with using organic solvent instead of ionic liquid for the first time. The space between the nanocomposite deposited on pencil and covered hallows fiber filled with air molecules. Linear response range was 7.70 × 10-6 to 1.42 × 10-4M, LOD and LOQ was obtained and finally was used for real analyt biological samples of urine and nail.

Keywords:

Capecitabine , DPV , Polyurethane Foam , Hallow Fiber , One-use Electrode