Biophysical approaches of the interaction between Pd(II) complex with malonate ligand and human serum albumin
عنوان مقاله: Biophysical approaches of the interaction between Pd(II) complex with malonate ligand and human serum albumin
شناسه ملی مقاله: ISPTC18_281
منتشر شده در هجدهمین همایش شیمی فیزیک ایران در سال 1394
شناسه ملی مقاله: ISPTC18_281
منتشر شده در هجدهمین همایش شیمی فیزیک ایران در سال 1394
مشخصات نویسندگان مقاله:
M Saeidifar - Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center, Karaj, Iran
A.A Saboury - Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
خلاصه مقاله:
M Saeidifar - Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center, Karaj, Iran
A.A Saboury - Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
Over the decades, there has been broad research in pharmaceutical chemistry to designeffective anticancer drugs, potentially valuable in the treatment of diverse cancers. A numberof palladium complexes with aromatic N- and N,N-containing ligands and N,O- containingligands as well as those with O-chelating ligand have been investigated as potential antitumordrugs [1,2]. Since it was very important to study of interaction mechanisms between drugsand serum albumin in aqueous solution in order to understand of the pharmacokineticbehavior of a drug and for the design of their analogues with effective pharmacologicalproperties. Herein, we present the binding properties of a new water-soluble palladium(II)malonate complex with HSA using various spectroscopic techniques under physiologicalconditions.
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/552740/