Synthesis of heteroarylated acetanilide derivatives in the presence of copper salts

Publish Year: 1395
نوع سند: مقاله کنفرانسی
زبان: English
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CHCONF03_187

تاریخ نمایه سازی: 8 اسفند 1395

Abstract:

Aryl pyridine derivatives are important building blocks in organic synthesis.[1] They have found widespread application in natural products, herbicides, surfactants, insecticides, pharmaceuticals and biologically active compounds.[2] The C–N bond forming reactions through C-H functionalization have emerged as one of the most important strategy in synthetic chemistry due to elimination of prefunctionalization step of the coupling partners.[3] In recent years, much attention has been paid to transition metals as C-H bond activating agents. Using inexpensive transition metals such as copper, as an activating agent for C-H bond activation, is economically of great importance. The use of cyanate salts as a coupling partner to form C-N bond have been reported rarely.in this work, the heteroarylated acetanilide derivatives are prepared from 2-arylpyridines in the presence of copper salts. By this protocol, various heteroarylated acetanilide derivatives are synthesized in good yields. 2-phenylpyridines containing electron-donating and electron-withdrawing groups are supposed to be well tolerated by this transformation

Authors

Ebrahim Kianmehr

School of Chemistry, College of Science, University of Tehran, Tehran, Iran

Yousef Amiri Lomedasht

School of Chemistry, College of Science, University of Tehran, Tehran, Iran

Nasser Faghih

School of Chemistry, College of Science, University of Tehran, Tehran, Iran