Synthesis of 2-Alkyl Pyridines via Copper Catalyzed Reactions

The chemistry and applications of N-oxide compounds have received much attention due to their synthetic usefulness and biological importance. Pyridine N-oxides often serve as important intermediates for the activation and functionalization of the pyridine ring[1].The C-H functionalization strategy has recieved substantial attention because of its economical, sustanable and environmentally benign features. Most reports are on palladium, rhodiom or ruthenium catalysis, and reports on copper catalysis are relatevly fewer[2]. Copper salts bear properties of cheapness and relatively low toxicity.So useing copper as a catalyst in organic synthesis are recieved much atention in recent years.Cross-dehydrogenative coupling reactions (CDC reactions) pioneered by Li, are direct oxidative C-C bond formation from two unactivated C-H bonds that eliminate the need for preactivation of both substrates.[3]In this work, an efficient and convenient synthetic route for the synthesis of 2-alkypyridines, which are important structural motifs in pharmaceutical and agrochemical products, will be presented