Degradation Behavior of PLGA-based In Situ Forming System in presence of hydroxyapatite

The degradation behavior of poly (lactic-co-glycolic acid) (PLGA) is important factors in selecting for use as a biomaterial. In this work, the influence of hydroxyapatite (HA) on the degradation rate of PLGA matrices wasstudied. The PLGA-based in situ forming system containing HA were prepared and the degradation behavior was studied in buffer phosphate (pH 7) at 37°C. The pH values of degradation media were evaluated for quantifyingerosion process. SEM techniques were employed to monitor the body structure of PLGA matrices during degradationtime. The results indicated that HA reduced the degradation rate of PLGA matrices