Magnetic Poly(urea-formaldehyde) Particles modified with β-Cyclodextrin

Magnetic polymer particles, in which the polymer matrix contains β-cyclodextrin, were synthesized. The prepared particles were examined by different analytical methods such as Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The results confirmed that the synthesis of particles was successfully carried out. These particles were employed for absorption and delivery of flutamide as a drug. And using UV-Vis spectrophotometer, impacts of such parameters as pH, time, temperature, and absorption capacity were examined in vitro. The results showed that the maximum drug absorption takes place at pH 4, in the first time interval of 10 min, and is poorly depend to temperature. Moreover, the drug release in simulated environment of intestine was carried out slowly. It is observed, that after 6 hours, more than of 50% of the drug was released