Preparation of Azithromycin loaded PVA/Chitosan electrospun nanofibers and investigation of drug release behavior in presence and Absence of Multi-walled carbon nanotubes

In this study ultrafine fibers of poly (vinyl alcohol) blend with chitosan were successfully prepared by electrospinning process as a pharmaceutical carrier of Azithromycin (AZI). AZI-loaded PVA/Chitosan films were manufactured using polymer solution containing different amounts of AZI in the presence and absence of Multi-walled carbon nanotubes (MWCNTs). The effect of solution properties on processability, morphological appearance and release behavior of the obtained fibers were investigated. AZI-loaded PVA/Chitosan films showed sustained release behavior, and altering the amount of AZI and the MWCNTs allowed us to control the amount of AZI released from these films; furthermore, the effect of MWCNTs demonstrated improvement in total AZI release behavior. In conclusion the results indicated the suitability of these particles as a drug delivery system and elucidate potential use of such system in biomedical application such as wound dressing

Keywords:

Drug Delivery , Electrospinning , PVA , Chitosan , Azithromycin , MWCNTs