Electrospun Biocompatible Core/Shell Polymer-Free Core Structure Nanofibers with Superior Antimicrobial Potency Against Multi Drug Resistance Organisms

This report, for the first time indicates simple coaxial spinneret electrospinning technique for fabrication of biomedicated core-shell fine Curcumin (Cur) nanofiber mats with polymer-free core. Polyvinyl alcohol (PVA) and Chitosan (CS) used as shell of nanofibers and Curcumin, as natural drug loaded into core of nanofibers (without any polymer) which preventing wound infections. A Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) images show that the prepared nanofibers were fine and uniform with clear core/sheath structure. FT-IR spectroscopy indicated convenient interactions between drug and polymers. The release profiles showed that core/shell nanofibers with polymer-free core could limited initial burst release of drug and gave improved sustainability in comparison with blend nanofibers. The antimicrobial activity experiment demonstrated that the activity of core/shell Cur/PVA-CS polymer-free core nanofibers have superior antimicrobial activity against methicillin resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis