Synthesis and characterization of temperature-responsive PVCL-based hydrogel as a nancarrier for drug delivery

In this study, novel temperature responsive hydrogel based on Poly(vinylcaprolactam) (PVCL) were prepared system via reversible addition-fragmentation chain-transfer (RAFT) polymerization, where PEG- diacrylate served as cross-linker, and Lysine used as linking agent and applied for drug delivery. First, PVCL-PEG nano-hydrogel was prepared by RAFT polymerization in dioxane solvent, and then lysine added to PVCL-PEG. After that, doxorubicin as an anti-cancer drug, was conjugated to lysine moiety of as-prepared structure via Schiff-base reaction. Obtained nano-gels were characterized by FTIR, 1HNMR and their effective sizes were checked by dynamic light scattering analysis. LCST were determined and the drug release profile was tested in vitro.

Keywords:

PVCL , Hydrogel , RAFT , Doxorubicin