3D nanofibrous scaffold for the regeneration of critical-size defects

In order to the regeneration of a damaged tissue, the key factor is to develop a three dimensional scaffold which mimics the microstructure, chemical composition and mechanical and functional properties of native tissue. In this work, an easy method for the fabrication of 3D scaffold from electrospun structures which possess modified porosity and enhanced pore size in addition to proper mechanical properties for load bearing applications is introduced. For this aim, coral microparticles were fixed between nanofibers and the fabricated mat was post-assembled into the cylindrical shape. The present work is the first report of using a mixed structure of polymer and natural coral. In fact this innovative method is established to make use of biopolymers advantageous in addition to natural coral benefits. In this article, fabrication method is explained and enhancement in porosity, pore size and mechanical properties are reported.