Perpetration and biological study of PCL nanofibrous with different roughness

Tissue engineering is used for regeneration and restoration of damaged tissues besides being used in medicine. Plasma surface modification is a convenient and cost-effective method for altering the surface properties of the polymeric biomaterials. In this study the effect of nano-fibers with different densities and plasma surface modification on the fibroblasts behaviour was evaluated.Poly caprolactone nanofibrous were fabricated by electrospinning technique. These nanofibrous were then surface modified by oxygen plasma techniques. Cellular activities were also studied by MTT test.These results showed that nanofibrous could support the cells growth and proliferation by developing 3D surface topography. The result of MTT test also showed that increase in time of spinning and using plasma oxygen surface modification of nanofibrous, by oxygen plasma, would result in the improvement the cells behaviour compared to the as a positive control.

Keywords:

tissue engineering , nanofibrous , surface modification , electrospinning , plasma