Effect Of Solvents On Vancomycin Release From An In Situ-Forming Controlled Drug Delivery System For Chronic Osteomyelitis Treatment

In situ-forming drug delivery is a new founding system that are consist of a biodegradable polymer and biocompatible solvent which is easily could trap antibiotics and become solids after injecting into targeted site and release drug in controlled manner in desired period of time. In this study, effects of solvent on vancomycin HCl release from injectable in situ forming implants (ISFIs) were investigated. Prepared ISFIs contain 60.3% solvent, 29.7% poly(DL-lactide-co-glycolide) (Resomer RG 504H) and 10% drug. Initial burst increased by using solvents in the rank of DMSO> Acetone > PEG 400> NMP and following drug release increased by using solvents in the rank of Acetone> DMSO> NMP> PEG 400. Between all formulations better release profile (initial burst 60% in the first day) was obtained with NMP. As a conclusion it was observed that hydrophobicity of solvents can be affected on control the release of drug from in situ forming implant systems.

Keywords:

Controlled Release Drug Delivery System , Vancomycin , PLGA , solvent