Zahra Shariatinia - Department of Chemistry, Amirkabir University of Technology (Polytechnic), P. O. Box: 159875-4413, Tehran, Iran.

Molecular dynamic (MD) simulations were applied to study the effect of solvents on the drug release from membranes consist of polyethylene glycol (PEG). Two different solvents including water and ethanol (100 molecules) were used as well as anticancer cyclophosphamide drug, five PEG chains each including ten repeating units in these simulations. The mean square displacement diagrams revealed that the drug mobility ishigher in the system made by ethanol

Molecular dynamic simulation, polyethylene glycol, cyclophosphamide, drug release