Preparation and Properties of Electron Beam Cross linked Hydrogels based on Poly (vinyl alcohol) (PVA), Poly (ethylene glycol) (PEG), Chitosan and Agar for Wound Dressing Applications

Application of hydrogels as biomaterials for dressing of burns and topical ulcers has been concerned specially in recent years.In the present research, novel kind of hydrogels were prepared based on aqueous solutions of Poly (vinyl alcohol) (PVA), Poly (ethylene glycol) (PEG), Chitosan and Agar. The prepared hydrogels then were exposed to electron beam irradiation with different doses in the range of 5-60 KGy to obtain the optimum dose. Effect of different parameters such as polymer molecular weight, radiation dose and blending ratios on the physical and mechanical properties were investigated. Biocompatibility tests also were performed on the samples in order to assess biological properties. After evaluating the optimum formulations and radiation dose the samples showed suitable biocompatibility properties

Keywords:

Hydrogel , Poly (vinyl alcohol) , Poly (ethylene glycol) , Chitosan , Radiation cross linking