Improving biocompatibility of the polyacrylonitlie nanofibrous scaffolds

Despite good properties of polyacrylonitrile (PAN), its application in biomedicine is limited because of biocompatibility issues. By functionalizing PAN with chitosan (CH), its biocompatibility will be improved. In this research, PAN nanofibers were obtained by electrospinning method. 8, 10, 12 and 15 % PAN solution in di-methylformamide were prepared and the nanofibers were produced in two different voltage; 15 and 20 Kv. By immersion PAN scaffolds in chitosan solution, they chemically linked together. Finally, cell growing and proliferation test was done on the scaffolds. Based on results, using 12 weight percent PAN solutions and applying 15Kv on system are the optimum conditions for electrospinning. Infrared Spectroscopy exhibits CH and PAN nanofibres linkaged. Furthermore, better biocompatibility was observed for modified PAN (CPAN) scaffolds

Keywords:

polyacrylonitrile , chitosan , biocompatibility , nanofibers , electrospinnig